Antimedi 0.5%

International Nonproprietary Name: Atipamezole Hydrochloride

Manufacturer: LLC “Biotecsi”

Country of Origin: Georgia

Dosage Form: Injectable solution

Target Species: Wild animals, ruminants, pigs, horses, dogs, cats

Pharmacological Group: Specific antagonist, receptor blocking agent (α2-antagonist)

Composition:
1 ml of injectable solution contains:

• Atipamezole Hydrochloride – 5 mg

• Sodium chloride – 9 mg

• Benzyl alcohol – 9 mg

• Water for injection – up to 1 ml

Description: Transparent, colorless solution

Packaging: 10 ml amber glass vial, sealed with a rubber stopper, aluminum cap, and polypropylene flip-off seal.

Pharmacological Properties

The drug belongs to the group of α2-antagonists.
Atipamezole hydrochloride selectively blocks α2-receptors, facilitating the release of the neurotransmitter norepinephrine in the central and peripheral nervous system. This increases neuronal activity and activates the sympathetic nervous system, counteracting the effects caused by activated α2-receptors due to medetomidine (Imomedin) or dexmedetomidine.

Atipamezole rapidly restores normal activity in animals; they wake up and can move. Its effect on the respiratory and cardiovascular systems is minimal, but when used after α2-agonists, sympathetic activity increases, resulting in elevated heart rate and arterial pressure.

After intramuscular administration, absorption is rapid; maximum plasma concentration is reached in 10–15 minutes; elimination half-life is about 1 hour. Metabolism occurs primarily in the liver, partially in the kidneys, and excretion is mainly via urine.

Indications for Use

Antimedi is used after the administration of Imomedin (medetomidine HCl) or dexmedetomidine to:

• Neutralize sedative and analgesic effects

• Reduce possible adverse effects on the cardiovascular and respiratory systems

Dosage and Administration

Administer intramuscularly (IM), once, 15 minutes after Imomedin injection and no later than 60 minutes after it. Usually, sedation caused by Imomedin is reversed, and the animal regains normal activity 5–10 minutes after Antimedi injection. If sedation persists, a repeated dose may be given 10–15 minutes after the first injection.

Dosage guidelines:

• Wild animals, ruminants, pigs, horses, dogs: Antimedi dose in μg/kg is 5 times the medetomidine dose; in ml, it equals the medetomidine dose.

• Cats: Antimedi dose in μg/kg is 2.5 times the medetomidine dose; in ml, it is half of the medetomidine dose.

Example:

• Wild and domestic animals, pigs, horses, dogs:

  • Medetomidine HCl dose: 0.4 ml/10 kg

  • Antimedi dose: 0.4 ml/10 kg

• Cats:

  • Medetomidine dose: 0.4 ml/5 kg

  • Antimedi dose: 0.2 ml/5 kg

Antimedi is also used after combined medetomidine HCl + ketamine anesthesia to accelerate recovery. In this case, the dose remains the same. Injection should be given no earlier than 30–40 minutes after ketamine injection.

Side Effects

• Dogs: Within the first 10 minutes, hypotension may occur. In rare cases, vomiting, defecation, short-term dyspnea, and muscle tremors.

• Cats: Possible hypothermia after administration.

Overdose

Overdose may cause transient hyperactivity and tachycardia. Symptoms are generally mild and resolve within a few hours. In cats, minimize external stimuli during hyperactivity.
Symptoms of overdose can be alleviated by administering half the dose of medetomidine HCl.

Contraindications

• Do not use during pregnancy and lactation

• Not intended for reversal of sedative effects caused by drugs other than α2-agonists

Special Precautions

• Use with caution in animals with liver disorders

• No established interaction with other drugs

Personal Safety Measures

Follow standard hygiene and safety rules when handling veterinary drugs. Wash hands thoroughly after use.
If contact with skin or eyes occurs, rinse immediately with plenty of water.
Individuals with hypersensitivity should avoid direct contact.
In case of accidental ingestion or allergic reaction, seek medical advice (bring product instructions or label).

Storage Conditions

Store at temperatures not exceeding 25°C, in original packaging, in a dry, dark place, away from food. Keep out of reach of children. Do not freeze.

Shelf life: 2 years; after opening, use within 28 days.
Do not use after expiration date. Dispose of unused product according to regulations.

Manufacturer’s Address:
Georgia, Tbilisi, Iumashvili St. #8