Rolenol

CLOSANTEL

INVESA, Spain

 

5% injection solution - transparent with yellow color.


Composition:


Closantel - - - - - - - - -  50mg.


 

Pharmacological characteristics:


Rolenol activity mechanism is determined by hindering oxidizing phosphorylation processes and damaging energetic change in parasitess, which is followed by the death of parasites. It is active against trematodes: Fasciola hepatica, Fasciola gigantica; It is active against following nematodes: Haemonchus placei, Oesophagostomum radiatum, Chabertia ovis,  Bunostomum sp; It is active against following worms: Hypoderma bovis, hypoderma lineatum, Oestrus ovis.


Rolenol is effective against grown-up parasites and their worms;


It is moderately toxic for warm-blooded animals. It isn't characterized by teratogenic and embriotoxic activities, if administered in recommended dose.

 

Pharmacokinetics:


Closantel is well absorbed from the place of injection and reaches all tissues and organs. Maximal concentration is reached in 8 hours after under-skin injection;


It is excreted from organism in a changed way. main amount is excreted via urine and very little via faeces; half excretion period includes 12 days;

 

Effects:


Treatment and prevention of parasite diseases in cattle, sheep and goats:


  • - Fasciliosis;
  • - Intestine nematodes (bunostomosis, hemonchosis, esophagostomiasis, cabertiosis);
  • - Invasions caused by botfly (hyperdermosis, estrosis);

 

Dosage:


Drug is designed for single usage;


Cattle - Drug is injected under skin or in muscles in case of fasciliosis and nematodoses - 0.5ml injection solution (25mg Closantel) on 10kg b/w;

In case of hyperdermosis - 1 ml solution (50mg Closantel) on 10kg b/w.


Sheep and goats - Fasciliosis - injection under skin - 1 ml solution (50mg Closantel) on 10kg b/w;


Nematodoses and estrosis - 0.5ml injection solution (25mg Closantel) on 10kg b/w;


It is recommended to make several injections at different places. After injection the injection area must be massaged;


Anti-hemninth processing of animals starts before moving animals to crib conditions or in spring before sending to meadows. Processing against botfly invasion is carried out after stopping flying of bodflies and in spring (February and March);

 

Side effects


No side effects are reported, if drug is administered in a recommended dose;

 

Contraindications:


The last third of gestation period; It isn't allowed to give drug to animals during the gestation period;

 

Special warning:


Drug must be tested on the small group of animals (10-15) before the mass usage; If no complications are revealed during 2-3 days of observation, drug can be used with other animals;


Animals can be slaughtered for the purpose of meat consumption after 28 days from the last injection. If animals are slaughtered earlier than this period, meat can be used as a food for furry animals of for production of meat and bone powder;


Hygiene and safety technique rules that are necessary during working with veterinary drugs must be observed in case of working with Rolenol;


It isn't allowed to use empty vial for other purposes;

 

Presentation:


Dark glass vials of 50ml, 100ml and 250ml;

 

Storage conditions and shelf life:


B list. Drug must be kept in dry place that is protected from light at 5-25°C temperature.

 

Shelf life - 3 years;

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